EVALUATION OF ACQUIRED CARDIAC COMPLICATIONS IN MAJOR -THALASSEMIC PATIENTS REFERRED TO AHVAZ THALASSEMIA CENTER

摘要: Background and Objective: To evaluate cardiac status in patients with thalassemia major. Subjects Methods: The investigation included thorough history taking, clinical examination, electrocardiography, chest radiography echocardiography. One hundred twenty young adults thalassemia, following an adequate transfusional chelation treatment regimen, without signs of cardiopulmonary involvement. Results: 63 were female 57 them male. Mean age the 16.6 6 years (range 5-37 yr). Abnormal findings ECG found 35.8% that most common nonspecific T wave ST segment changes. Chest radiograph revealed increased cardiothoracic ratio 30% patients. Precardial effusion reported 2.5%. No precarditis was any patient. Mitral, tricuspid pulmonary valve regurgitations observed 52%, 60% 20% respectively. None had frank congestive heart failure. Ejection fraction fractional shortening 55.2% 5 31% E/A 30 mmHg) 8.3% patients, aged 19±8 yr. PHT correlated positively irregular use desferal (P<0.001).Age negatively ejection (P<0.001), (P<0.05), mitral (p<0.003) (p < 0.014). In abnormal CXR; reduced significantly (P 0.004). Left ventricular (LV) systolic dysfunction encountered 23.3% 20 years. Restrictive LV filling suggestive 32% Conclusion: Despite regular usage standard transfusion, there is also chance complications thalassemics. Echocardiographic examination appears a tool more reliable than clinical, electrocardiographic and/or X ray assessment adult patient At present powerful predictive information includes patient’s transfusion record, serial serum ferritin levels, compliance to regimen. Sci Med J 2010;8(4):391-405