The enterohepatic physiology of 24,25-dihydroxyvitamin D3.

摘要: Products of intravenously administered [3H]24,25-dihydroxyvitamin D3 are excreted in the bile normocalcemic, vitamin D-replete rats. Within 3 and 24 hr, 7.3% +/- 1.4 18.5% (mean S.D.) dose appears bile. Three hours after instillation biliary products into duodena other 7.6% 2.05 newly secreted bile; at hr 21.1% 7.8 instilled is present These data suggest that 24,25-dihydroxyvitamin undergo an enterohepatic circulation. The metabolites much more polar than parent sterol as assessed by silicic acid chromatography high-performance liquid chromatographic techniques. retained on DEAE-cellulose presence methanol eluted upon addition acetic to eluting solvent. support existence a quantitatively important circulation E3; disturbances this metabolic pathway could help explain pathogenesis hepatic intestinal osteodystrophy.