Relative effectiveness of 12-hourly fractionation and a non-uniform x-ray schedule in the optimum fractionation of C3H mouse mammary tumours.

作者: J. F. Fowler , P. W. Sheldon , Susan R. Harris , Sally A. Hill , Sally E. Ayres

DOI: 10.1259/0007-1285-48-571-581

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摘要: Abstract In previous experiments the highest proportions of tumours controlled for 150 days at a particular level skin reaction were obtained with five or nine fractions X rays in ten respectively. Poor results same numbers given 4 18 The present work reports three “non-standard” fractionation schedules: two equal doses 12-hour intervals over four and one eight decreasing 11 days. interval schedules gave which to best by any other schedule tested. 8F/11d non-uniform schedule, however, mediocre spite being close previously optimum overall time. When these are compared published from tumour system, phases demonstrated. At short times, up days, situation is finely balanced, so th...

参考文章(12)
J. F. Fowler, The Rationale of Dose Fractionation Karger Publishers. ,vol. 3, pp. 6- 23 ,(1969) , 10.1159/000386971
J.F. Fowler, Juliana Denekamp, C. Delapeyre, Susan R. Harris, P.W. Sheldon, Skin reactions in mice after multifraction x-irradiation. International Journal of Radiation Biology. ,vol. 25, pp. 213- 223 ,(1974) , 10.1080/09553007414550271
M.M. Elkind, Recovery, reoxygenation and a strategy to improve radiotherapy Charles C Thomas, Springfield, IL. ,(1972)
C. G. Orton, F. Ellis, A simplification in the use of the NSD concept in practical radiotherapy British Journal of Radiology. ,vol. 46, pp. 529- 537 ,(1973) , 10.1259/0007-1285-46-547-529
J. F. Fowler, J. Denekamp, A. L. Page, A. C. Begg, S. B. Field, K. Butler, Fractionation with X rays and neutrons in mice: response of skin and C3H mammary tumours British Journal of Radiology. ,vol. 45, pp. 237- 249 ,(1972) , 10.1259/0007-1285-45-532-237
Juliana Denekamp, Changes in the rate of repopulation during multifraction irradiation of mouse skin. British Journal of Radiology. ,vol. 46, pp. 381- 387 ,(1973) , 10.1259/0007-1285-46-545-381
J.F. Fowler, P.W. Sheldon, A.C. Begg, S.A. Hill, A.M. Smith, Biological properties and response to x-rays of first-generation transplants of spontaneous mammary carcinomas in C3H mice. International Journal of Radiation Biology. ,vol. 27, pp. 463- 480 ,(1975) , 10.1080/09553007514550461
Frank Ellis, Dose, time and fractionation: A clinical hypothesis Clinical Radiology. ,vol. 20, pp. 1- 7 ,(1969) , 10.1016/S0009-9260(69)80043-7
P W Sheldon, J L Foster, J F Fowler, Radiosensitization of C3H Mouse Mammary Tumours by a 2-Nitroimidazole Drug British Journal of Cancer. ,vol. 30, pp. 560- 565 ,(1974) , 10.1038/BJC.1974.235
J.F. Fowler, S.B. Field, Juliana Denekamp, The effect of fractionated doses of neutrons on C3H mouse mammary tumours. European Journal of Cancer. ,vol. 10, pp. 281- 285 ,(1974) , 10.1016/S0014-2964(74)80017-4