Use of genome-wide high-throughput technologies in biomarker development.
作者： Sabine Classen , Andrea Staratschek-Jox , Joachim L Schultze
关键词:
摘要: In recent years, the usage of high-throughput technologies in fields genomics, transcriptomics, proteomics and metabolomics for biomarker discovery has expanded enormously. Biomarkers can be applied many purposes, including diagnosis, prognosis, staging selecting appropriate patient therapy. addition, biomarkers provide information on disease mechanism or progression. Biomarker development clinical application encompasses phases their characterization, assay and, finally, implementation using automated platforms employed laboratories. However, translation from bench to bedside outside a research-oriented environment proven more difficult. This is reflected by only few new being integrated into last years. article reviews currently used identification biomarkers, as well present approaches increase percentage that pass ...
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