A paradigm shift in vaccine production for pandemic influenza.

摘要: The recent introduction of an H5N8 subtype highly pathogenic avian influenza virus (HPAIV) into the United States from Asia is a timely reminder propensity viruses to undergo rapid global movement. subsequent reassortment this generate H5N2 variant, which has caused significant mortality in commercial poultry across America, similarly highlights potential HPAIV change quickly and unpredictably. Concurrent with US, H7N9 continues circulate birds China cause associated zoonotic infection humans, high case fatality rate confirmed cases. Although incidence human infections relatively low, outbreak persisted for more than 2 years spread throughout Eastern China, region large areas population density. Given current rate, if were acquire ability transmit efficiently its emergence immunologically naive would likely require major public health response.