Characterization of chemical stimuli for the penetration ofschistosoma mansoni cercariae

摘要: The stimulation of penetration ofSchistosoma mansoni cercariae into agar was studied. This depends exclusively on chemical triggers whose specificity is analyzed in experiments with 230 chemicals. Only aliphatic hydrocarbon chains which have a polar as well nonpolar end group are effective. effectiveness saturated substances limited, at pH 7.0, to chain lengths between 10 and 15 carbon atoms. Unsaturated active longer lengths. Their increased by the number double bonds thecis position, these should not be placed too close chain. As bonds, halogens, hydroxyl groups, methyl side equally All stimulating kill free water, appropriate chemicals cause this lethality very low concentrations. It shown that host recognition pattern stage especially adapted invasion human skin.