摘要: Hybrid male sterility is one of the most rapidly evolving postzygotic reproductive barriers, which has received special attention in study speciation. In Drosophila, majority interspecific crosses, hybrid males are sterile while females fertile. Why remains a fundamental question for evolutionary biologists. A number investigations have been carried out to understand causes and results suggest that it may involve either X-Y, X-autosomes, Y-autosomes, cytoplasmic incompatibilities or genes. The genetic basis nebulous, but seems involves large genes almost all chromosomes. only characterized speciation gene Drosophila today Odysseus, no functional tests yet reported support its role equivalence homeobox gene. To mechanism sterility, several theories proposed. three important dominance theory, faster-male theory faster-X among popular. Although studies on well documented, conclusive uniformly obeyed species still known. During last two decades, resurgence interest use as model organism such warrant comprehensive review this topic facilitate better understanding subject. view this, brief history recent advances field documented present article.