Interleukin-7 and lymphopoiesis: biological and clinical implications.

摘要: IL-7 was identified in 1988 following an intensive search for bone-marrow stromal cell growth factors involved early steps of B-cell genesis [1]. The role has since been expanded to include functions as a thymocyte factor and pre-T-cell differentiation factor, well activation monocytes macrophages, NK cells, cytolytic T lymphocytes (CTL’s), lymphokine-activated killer (LAK) activity. Several preclinical studies mice predict that may be use antitumor therapy acceleration lymphoid recovery lymphopenic patients. In addition, appears hold promise enhancing antimicrobial responses. This chapter describes detail the current status regulator lymphopoiesis effector function, potential therapeutic implications performed mice.