Tumor Heterogeneity: Will It Change What Pathologists Do.

摘要: Although the notion that tumors are heterogeneous is well rooted in diagnostic pathology, extent of this heterogeneity at molecular level and its impact on (targeted) treatment choice will certainly influence practice pathology. Even though consequences tumor for cancer care as yet incompletely understood, pathologists can contribute to solving major scientific clinical problems related by rethinking guidelines sampling, have a more comprehensive covering intratumor available tissue samples. They should develop and/or technology adequately document sample characteristics such percentage cells sample. need training bioinformaticians field pathobiology integrate well-trained workflow leading final pathology report. also redefine postgraduate programs address in-depth pathobiology. Pathologists might making public large aware importance data sharing. Finally, support creation consortia which shared with translational research community.