Antioxidative defense against omeprazole-induced toxicogenetical effects in Swiss mice.

摘要: Omeprazole (OME), a most frequently used proton pump inhibitor in gastric acidosis, is evident to show many adverse effects, including genetic instability. This study evaluated toxicogenic effects of OME Mus musculus. For this study, 40 male Swiss mice were divided into 8 groups (n = 5) and treated with at doses 10, 20, 40 mg/kg and/or the antioxidants retinol palmitate (100 IU/kg) ascorbic acid (2.0 μM/kg). Cyclophosphamide 50 mg/kg, (cytotoxic agent) vehicle served as positive negative control group, respectively. After 14 days treatment, stomach cells along bone marrow peripheral blood lymphocytes collected submitted comet assay (alkaline version) micronucleus test. Additionally, hematological biochemical parameters animals also determined inspect group. The results suggest that all induced genotoxicity mutagenicity cells. However, association antioxidants, these modulated inhibited DNA repair capacity. Taken together, (such acid) may be one best options counteract OME-induced cytogenetic