Elderly Patients with Painful Bone Metastases. The Impact of Comorbidity onthe Choice of Radiation Therapy Regimen

摘要: Background: The aim of this study was to demonstrate comparable pain relief with two schedules radiotherapy(RT) for painful bone metastases in elderly patients assessed at baseline the Cumulative Illness Rating Scale Geriatrics (CIRS-G). Materials and methods: 132 were analyzed. 77 received a single 8-Gy fraction 55 20 Gy 5 fractions. choice treatment schedule related comorbidity, disability, target size compliance. Pain intensity measured Numeral (NRS: 0=no pain; 10=high pain). Complete response defined reduction >3 three points, partial as ≥2 (2 ≤ 3), no by score<2. evaluation recorded 1-4-8 weeks after completing RT. Results: overall response: 90.3% 8 arm (49.8% complete 40.5% partial), 94.6% (44.6% 50%partial). No high grade toxicity reported. attained faster (p-value ~ 0.2). We observed maximum control significant differences noted between groups. re-treatment rate 17.6% vs. 11.1% respectively. Conclusions: arms terms response, toxicity. Our experience showed that not influenced age, but elderly, life expectancy, comorbidities evaluated CIRS-G, compliance, are crucial selecting shorter treatment.