Matrikine and matricellular regulators of EGF Receptor signaling on cancer cell migration and invasion

摘要: Cancer invasion is a complex process requiring, among other events, extensive remodeling of the extracellular matrix including deposition pro-migratory and pro-proliferative moieties. In recent years, it has been described that while invading through matrices cancer cells can change shape adapt their migration strategies depending on microenvironmental context. Although intracellular signaling pathways governing mesenchymal to amoeboid shift vice versa have mostly elucidated, signals promoting these shifts are largely unknown. this review, we summarize findings point matrikines bind specifically EGF receptor as matricellular molecules enable cell migrational plasticity promote invasion.