Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study.

摘要: Collapsing glomerulopathy in HIV and non-HIV patients: A clinicopathological follow-up study. Background (CG) is a pattern of renal injury that seen association with infection increasingly recognized patients. Methods review native kidney biopsies CG were diagnosed between 1979 1997 18 42 patients provided. Results similar terms age, sex ratio, serum creatinine, proteinuria, the extent collapsing sclerosing glomerular lesions, interstitial damage. slight female predominance was found both groups. In contrast to patients, group characterized by high prevalence blacks (94 vs. 57%), frequent tubuloreticular inclusions (76 29%), microcystic tubular changes (72 40%). 13 associated systemic lupus erythematosus (SLE)-like disease (5), hepatitis C virus (HCV) (3), HTLV-I infection, MCTD, acute monoblastic leukemia, multiple myeloma, cerebral arteritis. Overall, survival human immunodeficiency (HIV) not significantly different. Cox regression revealed had an adverse effect on short-term survival, other significant risk factors being extensive fibrosis, low percentage glomeruli collapse. The slope reciprocal creatinine best predicted degree proteinuria. Serum correlated male gender, Proteinuria effacement podocyte foot processes. Conclusions shares many similarities some autoimmune diseases, lymphoproliferative disorders, viral infections.