Method for increasing sensitivity to chemically induced terminal differentiation

作者: Richard A. Rifkind , Paul A. Marks , Ronald Breslow , Sandro Pontremoli

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摘要: The present invention provides a method of selectively inducing terminal differentiation neoplastic cells and thereby inhibiting proliferation such which comprises treating the so as to render them resistant an antitumor agent contacting resulting under suitable conditions with amount compound effective induce cells. has structure: [R-A ]-B-[A1 -B1 -]a [A2 -B2 -]b [A3 -R1 ]. also concerns patient having tumor characterized by administering subsequently inhibit their proliferation.

参考文章(4)
Alberto Haces, Theodore Breitman, John S. Driscoll, Chemical differentiating agents ,(1987)
Akira Kawarada, Yukio Inoue, Shinichiro Esumi, Shozo Kawabata, Tsuneo Saita, Setsuo Takeuchi, Keiji Sekine, Makoto Yamamoto, Kaguya Sasaki, Mutsuyuki Kochi, A composition and method of treating selected malignant conditions ,(1987)