The consequences of chorioamnionitis: preterm birth and effects on development.

摘要: Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis common preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, rupture membranes, less than subclinical/histologic which asymptomatic defined inflammation the chorion, amnion, placenta. often associated with fetal inflammatory response. The response syndrome (FIRS) increased systemic cytokine concentrations, funisitis, vasculitis. epidemiological studies have demonstrated that FIRS leads to poor cardiorespiratory, neurological, renal outcomes. These observations are further supported experimental improved our understanding mechanisms responsible for these This paper outlines clinical current chorioamnionitis-induced explores cellular physiological underlying neural, retinal, outcomes observed in infants exposed chorioamnionitis.