Aortic media explants. Cell proliferation and production of mucopolysaccharides, collagen, and elastic tissue.

摘要: Abstract Segments of pig aortic medial tissue, cultured in a semisynthetic medium, develop new growth starting about the fourth day. In first week most cells this are primitive and fibroblast-like with only few modified smooth muscle cells. At period, mucopolysaccharides can be identified extracellular substances. By third week, great majority The substance is composed collagen elastic tissue addition to mucopolysaccharides. Since two phenomena, cell proliferation production these specific substances, among prominent features early atherosclerosis, it would seem that vitro system could used advantageously experiments designed study role individual factors implicated atherogenesis.