Experimental Rationale for Therapy in the Treatment of Acute Leukemia

摘要: The treatment of human leukemia from a scientific approach marks its beginnings the mid 1950’s with establishment group clinicians at National Cancer Institute which included Drs. Frei, Holland, Zubrod and Freireich. Concomitant this clinical program was development least 3 major experimental programs: two in therapeutics headed by Dr. Abraham Goldin NCI Howard Skipper Southern Research Institute, one pharmacology under Rall NCI. history these groups cross-fertilization concepts between laboratory clinic has become model for interaction bench investigators (1). I will attempt here to review some facets role played experimentalists such as using models therapy.