Influence of the V(D)J recombination mechanism on the formation of the primary T and B cell repertoires.

摘要: T and B cells exploit the mechanism of V(D)J recombination to make diverse or very restricted repertoires at varying times during ontogeny. Fetal are limited since there no N nucleotides. Also, if short sequence homologies present near coding ends, junctions preferentially made that site. For gamma delta TCR, a lesser extent for Ig, this results in homogeneous population early alpha beta however, have paucity homologous stretches, maintain junctional diversity newborn. In both newborns adults, some ends show nucleotide deletion, while others heterogeneous extensive deletion. It appears sequences been selected through evolution as control repertoire formation.