Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System

摘要: Abstract Circadian rhythms are daily that regulate many biological processes – from gene transcription to behavior and a disruption of these can lead myriad health risks. entrained by light, their 24-hour oscillation is maintained core molecular feedback loop composed canonical circadian (“clock”) genes proteins. Different modulators help maintain the proper rhythmicity proteins, one emerging modulator dopamine. Dopamine has been shown have circadian-like activities in retina, olfactory bulb, striatum, midbrain, hypothalamus, where it regulates, regulated by, clock some areas. Thus, likely dopamine essential mechanisms five brain This review discusses studies showcase different dopaminergic may be involved with regulation areas’ rhythms. Mechanisms include how receptor activity directly indirectly influence dopamine’s interactions gap junctions neuronal excitability, release effects gated low- high-pass filters. Because neurons described this also inhibitory neurotransmitter GABA which influences protein expression we discuss articles explore contribute actions on Finally, understand loss function could rhythms, linking neurodegenerative disease Parkinson’s Disease disruptions The purpose summarize growing evidence regulating either or indirectly, areas discussed here. An appreciation new treatments including pharmacological agents directed at alleviating various symptoms rhythm disruption.