Fetal Spinal Cord Transplants Support Growth of Supraspinal and Segmental Projections after Cervical Spinal Cord Hemisection in the Neonatal Rat
作者： Pamela S. Diener , Barbara S. Bregman
DOI: 10.1523/JNEUROSCI.18-02-00779.1998
关键词:
摘要: Cervical spinal cord injury at birth permanently disrupts forelimb function in goal-directed reaching. Transplants of fetal tissue permit the development skilled use and associated postural adjustments ([Diener Bregman, 1998][1], companion article). The aim this study was to determine whether transplants support remodeling supraspinal segmental pathways that may underlie recovery reflexes movements. Although brainstem-spinal projections cervical are present birth, reaching has not yet developed. Three-day-old rats received a overhemisection with or without transplantation (embryonic day 14); unoperated pups served as normal controls. Neuroanatomical tracing techniques were used examine organization CNS influence target-directed In animals hemisections only, corticospinal, brainstem-spinal, dorsal root within decreased number extent. contrast, receiving plus exhibited growth these throughout transplant over long distances host caudal transplant. Raphespinal axons apposed numerous propriospinal neurons control animals; associations greatly reduced lesion-only animals. These observations suggest after neonatal injury, embryonic axonal specifically input neurons. We rat, transplant-mediated reestablishment circuitry is mechanism underlying adjustments. [1]: #ref-38
sci-hub.st 参考文章(65)
M. Mcatee, B. S. Bregman, Hai Ning Dai, C. James, P. S. Diener, Intervention strategies to enhance anatomical plasticity and recovery of function after spinal cord injury. Advances in Neurology. ,vol. 72, pp. 257- 275 ,(1997)
Barbara Sypniewski Bregman, Holli Bernstein-Goral, Ellen Kunkel-Bagden, CNS transplants promote anatomical plasticity and recovery of function after spinal cord injury. Restorative Neurology and Neuroscience. ,vol. 2, pp. 327- 338 ,(1991) , 10.3233/RNN-1991-245622
B. Alstermark, A. Lundberg, S. Sasaki, Integration in descending motor pathways controlling the forelimb in the cat. 12. Interneurones which may mediate descending feed-forward inhibition and feed-back inhibition from the forelimb to C3-C4 propriospinal neurones. Experimental Brain Research. ,vol. 56, pp. 308- 322 ,(1984) , 10.1007/BF00236286
Peter Sterling, Henricus G.J.M. Kuypers, Anatomical organization of the brachial spinal cord of the cat. III. The propriospinal connections Brain Research. ,vol. 7, pp. 419- 443 ,(1968) , 10.1016/0006-8993(68)90008-5
Barbara S. Bregman, Ellen Kunkel-Bagden, Marietta McAtee, Andrea O'Neill, Extension of the critical period for developmental plasticity of the corticospinal pathway. The Journal of Comparative Neurology. ,vol. 282, pp. 355- 370 ,(1989) , 10.1002/CNE.902820304
Barbara S. Bregman, Development of serotonin immunoreactivity in the rat spinal cord and its plasticity after neonatal spinal cord lesions. Brain Research. ,vol. 34, pp. 245- 263 ,(1987) , 10.1016/0165-3806(87)90213-6
B. Alstermark, A. Lundberg, U. Norrsell, E. Sybirska, Integration in descending motor pathways controlling the forelimb in the cat. 9. Differential behavioural defects after spinal cord lesions interrupting defined pathways from higher centres to motoneurones. Experimental Brain Research. ,vol. 42, pp. 299- 318 ,(1981) , 10.1007/BF00237496
Ellen Kunkel-Bagden, Hai-Ning Dai, Barbara S. Bregman, Recovery of function after spinal cord hemisection in newborn and adult rats: differential effects on reflex and locomotor function. Experimental Neurology. ,vol. 116, pp. 40- 51 ,(1992) , 10.1016/0014-4886(92)90174-O
DONALD G. LAWRENCE, HENRICUS G. J. M. KUYPERS, The functional organization of the motor system in the monkey. II. The effects of lesions of the descending brain-stem pathways. Brain. ,vol. 91, pp. 15- 36 ,(1968) , 10.1093/BRAIN/91.1.15
M. Illert, A. Lundberg, R. Tanaka, Integration in descending motor pathways controlling the forelimb in the cat. 1. Pyramidal effects on motoneurones. Experimental Brain Research. ,vol. 26, pp. 509- 519 ,(1976) , 10.1007/BF00238824