Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves
作者： M. Reinecke , W. G. Forssmann
DOI: 10.1007/BF00496578
关键词:
摘要: With the use of several region-specific antisera and peroxidase-antiperoxidase (PAP) technique, regulatory polypeptides were localized in nerves kidney. Neuropeptide Y (NPY)- immunoreactivity (IR), neurotensin (NT)-IR vasoactive intestinal polypeptide (VIP)-IR occurred at high densities all segments renal arterial system forming a perivascular plexus. Furthermore, NT-IR particularly frequent juxtaglomerular apparatus (JGA). Calcitonin gene-related peptide (CGRP)-IR was mainly concentrated supplying hilus arteries JGA. Substance P (SP)-IR predominantly found large varicosities close to vessels vicinity Somatostatin (SOM)-IR only observed single located media-adventitia border arteries. The peptidergic are correlated their ultrastructural counterpart. In addition, distribution patterns frequency different types nerve fibres evaluated compared. functional role these neuropeptides origin within efferent branch this part peripheral autonomic nervous is discussed. implication some studied afferent innervation also substantiated.
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