Nicotinic receptors and functional regulation of GABA cell microcircuitry in bipolar disorder and schizophrenia.

摘要: Studies of the hippocampus in postmortem brains from patients with schizophrenia and bipolar disorder have provided evidence for a defect GABAergic interneurons. Significant decreases expression GAD67, marker GABA cell function, been found repeatedly several different brain regions that include hippocampus. In this region, nicotinic receptors are thought to play an important role modulating activity interneurons by influences excitatory cholinergic afferents on their activity. disorder, influence appears be particularly prominent stratum oriens sectors CA3/2 CA1, two sites where these cells constitute exclusive neuronal type. sector CA3/2, layer receives robust projection basolateral amygdala (BLA) is central regulating at locus. Using laser microdissection, recent studies focused selectively layers associated using microarray technology. The results support idea neurons loci progression cycle repair damaged DNA. there reduction mRNAs subunit isoforms. These could reflect diminished receptor system cells, preponderance abnormalities observed studies. fibers medial septum may converge glutamatergic BLA result disturbances genomic functional integrity, ones induce disruptions integration microcircuitry within region.