Clinical significance of TLR1 I602S polymorphism for patients with metastatic colorectal cancer treated with FOLFIRI plus bevacizumab
作者： Satoshi Okazaki , Fotios Loupakis , Sebastian Stintzing , Shu Cao , Wu Zhang
DOI: 10.1158/1535-7163.MCT-15-0931
关键词:
摘要: The purpose of this study was to evaluate the clinical significance single-nucleotide polymorphisms in TLR1, TLR2, TLR6, and TAK1 patients with metastatic colorectal cancer (mCRC). We genotyped 9 SNPs mCRC treated first-line FOLFIRI (combination therapy irinotecan, 5-fluorouracil, folinic acid) plus bevacizumab, using a discovery cohort (TRIBE trial, n = 228) validation (FIRE-3 297), analyzed for association response rate (RR), progression-free survival (PFS), overall (OS). There significant TLR1 rs5743618 (T1805G) outcome. In TRIBE cohort, homozygous wild-type genotype (T/T) associated significantly lower RR compared variant T/G G/G genotypes (43% vs. 62%, P 0.025), observation validated FIRE-3 (46% 65%, 0.021). addition, those T/T had worse PFS (median, 8.2 10.5 months; HR, 1.57; 95% CI, 1.09-2.28, 0.014) OS (median: 19.9 27.9 1.63; 1.14-2.35, 0.007), other cohort. These differences remained statistically multivariate analysis. Our data suggest that could serve as predictor bevacizumab mCRC. Mol Cancer Ther; 15(7); 1740-5. ©2016 AACR.
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