作者: Esteban C. Dell'Angelica
DOI: 10.1016/S0962-8924(01)02043-8
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摘要: Clathrin plays a key function in membrane and protein trafficking through the endocytic late secretory pathways. Its role as molecular scaffold that drives formation of transport vesicles requires binding to number proteins with distinct functional structural properties. Recent studies have revealed most these interact clathrin surprisingly simple, linear arrangements acidic hydrophobic amino acid residues. This article discusses different types clathrin-binding motifs well physiological significance clathrin-dependent events.