Capillary Electrophoresis-Mass Spectrometry of Biologically Active Peptides and Proteins
作者： Stephen Naylor , Andy J. Tomlinson
DOI: 10.1007/978-1-59259-120-6_16
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摘要: Capillary electrophoresis (CE) is characterized by rapid analysis times and ultra-high resolution capabilities. Indeed, these characteristics, in conjunction with low sample consumption improved analyte recovery, were expected to revolutionize the of complex biological mixtures peptides proteins (1–3). Furthermore, family CE separation techniques affords numerous other mechanisms that differ from high-performance liquid chromatography (HPLC) proteins. In addition free solution separations such as capillary zone (CZE) (4),analyte can also be effected isoelectric focusing (IEF) (5–8), isotachophoresis (9), molecular weight sieving (10), micellar electrokinetic (MEKC) (11).
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