Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
作者： Helen C Fox , Dongju Seo , Keri Tuit , Julie Hansen , Anne Kimmerling
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摘要: Cocaine dependence is associated with increased stress and drug cue-induced craving physiological arousal but decreased prefrontal activity to emotional cognitive challenge. As these changes are relapse risk, we investigated the effects of α2 receptor agonist guanfacine on processes. Twenty-nine early abstinent treatment-seeking cocaine dependent individuals were randomly assigned either daily placebo or (up 3 mg) for four weeks. In a laboratory experiment, all patients exposed three 10-min guided imagery conditions (stress/stress, cue/drug cue, stress/drug cue), one per day, consecutively in random, counterbalanced order. Subjective craving, anxiety as well cardiovascular output assessed repeatedly. Brain response stress, cue relaxing was also during functional magnetic resonance (fMRI) imaging session. current study, found be safe well-tolerated. Lower basal heart rate blood pressure observed versus group. Guanfacine lowered nicotine arousal. The group showed medial lateral following exposure compared placebo. Data suggest further exploration warranted terms its potential reducing stress-induced
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