Dual regulation of lin28a by Myc is necessary during zebrafish retina regeneration

摘要: Cellular reprogramming leading to induction of Muller glia-derived progenitor cells (MGPCs) with stem cell characteristics is essential for zebrafish retina regeneration. Although several regeneration-specific genes are characterized, the significance MGPC-associated Mycb remains unknown. Here, we show that early expression induces like ascl1a, a known activator lin28a in MGPCs. Notably, mycb simultaneously activated by Ascl1a and repressed Insm1a regenerating retina. unravel dual role expression, both as an through MGPCs repressor combination Hdac1 neighboring cells. Myc inhibition reduces number abolishes normal collaboration inhibits her4.1, effector Delta-Notch signaling. Further, also repressive signaling on post-injured Our studies reveal mechanistic understanding pathway during regeneration, which could pave way therapeutic intervention mammalian