A glucose biosensor based on surface-enhanced Raman scattering: improved partition layer, temporal stability, reversibility, and resistance to serum protein interference.

摘要: This work updates the recent progress made toward fabricating a real-time, quantitative, and biocompatible glucose sensor based on surface-enhanced Raman scattering (SERS). The design relies an alkanethiolate tri(ethylene glycol) monolayer that acts as partition layer, preconcentrating near SERS-active surface. Chemometric analysis of captured SERS spectra demonstrates is quantitatively detected in physiological concentration range (0-450 mg/dL, 0-25 mM). In fact, 94% predicted concentrations fall within regions A B Clarke error grid, making acceptable predictions clinically relevant range. data presented herein also demonstrate provides stable for at least 3 days, substrate candidate implantable sensing. Glucose reversibility reusability evaluated alternately exposed to saline solutions; after each cycle, difference reveal partitioning process largely reversible. Finally, successfully partitions even when challenged with bovine serum albumin, protein mimic.