Occupational exposures and risk of systemic lupus erythematosus: a review of the evidence and exposure assessment methods in population- and clinic-based studies.

摘要: Epidemiologic and experimental research suggests a potential role of occupational exposures in the development systemic lupus erythematosus (SLE). A plausible association has been identified studies silica exposure SLE, complemented by lupus-prone mice exploring mechanisms related to apoptosis immune dysregulation. Experimental solvent trichloroethylene provide evidence effects on function, including increased production autoantibodies activation CD4+ T cells. However, few SLE have conducted, those that are available show little an association. There is some suggestion from influence pesticides but as with solvents, specific type may be implicated not known. Our understanding could advanced larger, multisite or parallel utilize similar questionnaire evaluation methods. Multiple using comparable measures needed sufficient sample size for examining gene-environment interactions. We general overview data requirements methods assessment clinical population-based SLE.