Genetics and Molecular Mechanisms in Oral Cancer Progression

作者: Prashanth Panta , Bramanandam Manavathi , Siddavaram Nagini

DOI: 10.1007/978-3-319-61255-3_2

关键词:

摘要: Exposure to tobacco in smoke or chewable form, isolation association with other risk factors (i.e., alcohol areca nut), disturbs the balanced expression of numerous genes and leads loss coordination their downstream signaling pathways, finally leading oral cancer. Initially changes like mild dysplasia benign hyperplasia are reversible, but continuous exposure carcinogens accumulation mutations multiple involved cell proliferation, differentiation, apoptosis, telomere maintenance, invasion, angiogenesis, resulting abnormal behavior immortalization. Gains losses occur on many chromosomal arms, a well-characterized mutational landscape is associated This chapter discusses wide spectrum genetic epigenetic events that take place oncogenes tumor suppressor special reference oncogenic miRs (miR-21, miR-31, miR-146a, miR-134, miR-184, miR-7, miR-127, miR-518c-5p), (miR-200 family, miR-101, miR-26a/b, miR-29a, miR-27b, miR-137, miR-125a, miR-491-5p, miR-124, miR-125, miR-218, miR-99a, miR-375), long noncoding RNA (HOTAIR, FOXCUT, MALAT1, UCA1, TUG1, CCAT2, FTH1P3, H19, HIFCAR/MIRHG) influence pathways enable acquisition cancer hallmarks.

参考文章(285)
Changxi Zhou, Yang Chen, Jie Yao, Xiangqun Fang, Hui Mao, Peiliang Geng, Fei Pan, A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 2838- 2849 ,(2014)
Chung-Ji Liu, Wilma Grace Shen, Shih-Yuan Peng, Hui-Wen Cheng, Shou-Yen Kao, Shu-Chun Lin, Kuo-Wei Chang, miR‐134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene International Journal of Cancer. ,vol. 134, pp. 811- 821 ,(2014) , 10.1002/IJC.28358
Sumihito Nobusawa, Hideaki Yokoo, Junko Hirato, Akiyoshi Kakita, Hitoshi Takahashi, Takashi Sugino, Kazuhiro Tasaki, Hideaki Itoh, Tsutomu Hatori, Yoshie Shimoyama, Atsuko Nakazawa, Shigeru Nishizawa, Hiroshi Kishimoto, Keiko Matsuoka, Masahiro Nakayama, Naoki Okura, Yoichi Nakazato, Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes. Brain Pathology. ,vol. 22, pp. 689- 697 ,(2012) , 10.1111/J.1750-3639.2012.00574.X
Pauline M. W. Kempen, Rob Noorlag, Weibel W. Braunius, Cathy B. Moelans, Widad Rifi, Suvi Savola, Ronald Koole, Wilko Grolman, Robert J. J. Es, Stefan M. Willems, Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma. Cancer Medicine. ,vol. 4, pp. 1525- 1535 ,(2015) , 10.1002/CAM4.499
C M Fife, J A McCarroll, M Kavallaris, Movers and shakers: cell cytoskeleton in cancer metastasis British Journal of Pharmacology. ,vol. 171, pp. 5507- 5523 ,(2014) , 10.1111/BPH.12704
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Yu Usami, Ken Ishida, Sunao Sato, Mitsunobu Kishino, Megumi Kiryu, Yuzo Ogawa, Masaya Okura, Yasuo Fukuda, Satoru Toyosawa, Intercellular adhesion molecule-1 (ICAM-1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion. International Journal of Cancer. ,vol. 133, pp. 568- 578 ,(2013) , 10.1002/IJC.28066
Thomas Fillies, Richard Werkmeister, Jens Packeisen, Burkhard Brandt, Philippe Morin, Dieter Weingart, Ulrich Joos, Horst Buerger, Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity BMC Cancer. ,vol. 6, pp. 10- 10 ,(2006) , 10.1186/1471-2407-6-10
Tanmoy Mondal, Santhilal Subhash, Roshan Vaid, Stefan Enroth, Sireesha Uday, Björn Reinius, Sanhita Mitra, Arif Mohammed, Alva Rani James, Emily Hoberg, Aristidis Moustakas, Ulf Gyllensten, Steven J.M. Jones, Claes M Gustafsson, Andrew H Sims, Fredrik Westerlund, Eduardo Gorab, Chandrasekhar Kanduri, MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures Nature Communications. ,vol. 6, pp. 7743- 7743 ,(2015) , 10.1038/NCOMMS8743