Testicular dysgenesis does not affect expression of anti-müllerian hormone by Sertoli cells in premeiotic seminiferous tubules.

摘要: Anti-Mullerian hormone (AMH) immunoreactivity was studied on paraffin sections obtained from archival testicular biopsies of 29 children with intersex disorders and 22 controls. Strong AMH observed in Sertoli cell cytoplasm 8 fetal weeks until puberty. During pubertal maturation, both normal patients, expression present premeiotic seminiferous tubules, but no longer detected neighboring tubules meiotic development. immunostaining abolished the testis one patient persistent Mullerian ducts due to a mutation gene, conserved testes two patients mutations receptor gene. Testicular dysgenesis usually results sexual ambiguity, low testosterone serum levels persistence derivatives. dysgenetic testes, also sex-cord cells gonadoblastoma. In asymmetric gonadal differentiation, streak gonad AMH-negative. conclusion, secretion is constitutive feature immature its altered only by not dysgenesis. The degree regression reflect number, functional value, testis.