The C-type lectin-like receptors of Dectin-1 cluster in natural killer gene complex.

摘要: Natural killer gene complex (NKC) encodes a group of proteins with single C-type lectin-like domain, (CTLD) which can be subdivided several subfamilies according to their structures and expression patterns. The receptors containing the conserved calcium binding sites in CTLD fold belong II lectin superfamily are expressed on myeloid cells non- cells. lacking have evolved bind ligands other than carbohydrates independently thereby named as receptors. previously thought exclusively natural (NK) enable NK discriminate self, missing self or altered self. However, some identified intensely investigated, recently. These receptors, especially Dectin-1 cluster, wide variety ligands, including those exogenous origin, play important roles physiological functions pathological processes immune homeostasis, defenses, surveillance. In this review, we summarize each member structural profiles, patterns, signaling properties well known functions.