Weight Loss Reduces Circulating Asymmetrical Dimethylarginine Concentrations in Morbidly Obese Women
作者： Katarzyna Krzyzanowska , Friedrich Mittermayer , Hans-Peter Kopp , Michael Wolzt , Guntram Schernthaner
DOI: 10.1210/JC.2004-0672
关键词:
摘要: The endogenous nitric oxide-synthase inhibitor asymmetrical dimethyl-l-arginine (ADMA) is elevated in patients with increased risk for arteriosclerosis. Obesity a factor cardiovascular disease. We measured plasma ADMA concentrations morbidly obese women before and after weight loss following gastroplastic surgery. symmetrical were analyzed by HPLC from 34 female (age 41 ± 7 yr) body mass index (BMI) of 49 1 kg/m2 14 months vertical ring gastroplasty. Age-matched healthy (BMI < 25 kg/m2; n = 24) studied as controls. After surgery, BMI decreased to (P 0.00001), reduced 1.06 0.06 μmol/liter at baseline 0.81 0.04 0.00001). Symmetrical levels not affected. correlated high-sensitivity C-reactive protein (r 0.42; P 0.05) weig...
oup.com
endojournals.org参考文章(49)
Carl Nathan, Nitric oxide as a secretory product of mammalian cells. The FASEB Journal. ,vol. 6, pp. 3051- 3064 ,(1992) , 10.1096/FASEBJ.6.12.1381691
Akira Ito, Kensuke Egashira, Takahiro Narishige, Kouhei Muramatsu, Akira Takeshita, Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension. Japanese Circulation Journal-english Edition. ,vol. 65, pp. 775- 778 ,(2001) , 10.1253/JCJ.65.775
Akira Ito, Philip S. Tsao, Shanthi Adimoolam, Masumi Kimoto, Tadashi Ogawa, John P. Cooke, Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation. ,vol. 99, pp. 3092- 3095 ,(1999) , 10.1161/01.CIR.99.24.3092
Rainer H. Böger, Stefanie M. Bode-Böger, Wolfgang Thiele, Wolfgang Junker, Klaus Alexander, Jürgen C. Frölich, Biochemical Evidence for Impaired Nitric Oxide Synthesis in Patients With Peripheral Arterial Occlusive Disease Circulation. ,vol. 95, pp. 2068- 2074 ,(1997) , 10.1161/01.CIR.95.8.2068
S Jonsson, B Hedblad, G Engström, P Nilsson, G Berglund, L Janzon, Influence of obesity on cardiovascular risk. Twenty-three-year follow-up of 22,025 men from an urban Swedish population. International Journal of Obesity. ,vol. 26, pp. 1046- 1053 ,(2002) , 10.1038/SJ.IJO.0802060
GJ Blake, PM Ridker, None, Inflammatory Bio-Markers and Cardiovascular Risk Prediction Journal of Internal Medicine. ,vol. 252, pp. 283- 294 ,(2002) , 10.1046/J.1365-2796.2002.01019.X
Markus C Stühlinger, Fahim Abbasi, James W Chu, Cindy Lamendola, Tracey L McLaughlin, John P Cooke, Gerald M Reaven, Philip S Tsao, Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA. ,vol. 287, pp. 1420- 1426 ,(2002) , 10.1001/JAMA.287.11.1420
Anders Pettersson, Lotta Uggla, Viveca Backman, Determination of dimethylated arginines in human plasma by high-performance liquid chromatography Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 692, pp. 257- 262 ,(1997) , 10.1016/S0378-4347(96)00525-7
Hiroshi Azuma, Jun Sato, Hidehisa Hamasaki, Akiko Sugimoto, Eiji Isotani, Satoshi Obayashi, Accumulation of endogenous inhibitors for nitric oxide synthesis and decreased content of L‐arginine in regenerated endothelial cells British Journal of Pharmacology. ,vol. 115, pp. 1001- 1004 ,(1995) , 10.1111/J.1476-5381.1995.TB15910.X
Carlos Hermenegildo, Pascual Medina, Marta Peiró, Gloria Segarra, José M. Vila, Joaquín Ortega, Salvador Lluch, Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients. The Journal of Clinical Endocrinology and Metabolism. ,vol. 87, pp. 5636- 5640 ,(2002) , 10.1210/JC.2002-020905