Impact of guideline-concordant empiric antibiotic therapy in community-acquired pneumonia.

摘要: Abstract Purpose We evaluated the impact of guideline-concordant empiric antibiotic therapy on time to clinical stability, switch therapy, length hospital stay, and mortality among patients with community-acquired pneumonia. Methods This is a retrospective cohort study all adult pneumonia managed at 5 community hospitals from November 1, 1999 April 30, 2000. Patients were stratified into discordant groups as defined by 2001 American Thoracic Society 2003 Infectious Diseases America guidelines. Time in-hospital in per-protocol intention-to-treat stepwise regression models that included outcome dependent variable, independent Pneumonia Severity Index score covariate. Results Of 631 evaluable patients, 357 (57%) received therapy. Groups similar respect age, sex, comorbidities, severity illness, processes care. Guideline-concordant was associated significant decrease (P ≤.01), stay (P = .04) for both analyses. In addition, stability analysis only (P = .03). Conclusions Among hospitalized improved survival shorter stay.