Pediatric Neuromyelitis Optica Spectrum Disorders.

摘要: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating the central nervous system that can occur in children adults. The classic presentation NMOSD is characterized by optic neuritis transverse myelitis, but other presentations also recognized, expanding disease as NMO disorders. purpose this review to discuss clinical features, along with management treatment options, including potential future therapeutic pediatric NMOSD. aquaporin-4 antibody (AQP4 ab) specific for NMOSD; however, recently another antibody, myelin oligodendrocyte glycoprotein (MOG has been found subset AQP4 ab-negative patients children. Most studies reported adults, retrospective on efficacy safety mycophenolate mofetil, azathioprine, rituximab available. While some NMOSD-specific available, more research needed mechanisms early onset options children, whether different considerations ab opposed MOG ab-positive disease.