N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat
作者： G.J. Prieto , J.T. Cannon , J.C. Liebeskind
DOI: 10.1016/0006-8993(83)91282-9
关键词:
摘要: We previously found that the opiate antagonist, naloxone, partially blocks stimulation-produced analgesia (SPA) elicited from ventral but not dorsal regions of medial midbrain in rats. The present study compares effects n. raphe magnus (NRM) lesions on SPA these same two areas. thresholds were measured with tail-flick method and compared before for up to weeks after NRM lesions. A high positive correlation was between percent destruction increase threshold rats electrode placements. Damage brain areas other than seemed contribute effects. conclude is a critical relay pain-suppressive path area rat mediating an opioid form analgesia.
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sci-hub.se 参考文章(17)
Fuxe K, Dahlstroem A, EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. Acta Physiologica Scandinavica. ,vol. 62, pp. 1- 55 ,(1964)
Louis J. Pellegrino, Anna J. Cushman, A stereotaxic atlas of the rat brain Published in <b>1967</b> in New York NY) by Appleton-Century-Crofts. ,(1967)
L.R. Watkins, G. Griffin, G.R. Leichnetz, D.J. Mayer, Identification and somatotopic organization of nuclei projecting via the dorsolateral funiculus in rats: a retrograde tracing study using HRP slow-release gels. Brain Research. ,vol. 223, pp. 237- 255 ,(1981) , 10.1016/0006-8993(81)91139-2
Masamichi Satoh, Akinori Akaike, Takahiro Nakazawa, Hiroshi Takagi, Evidence for involvement of separate mechanisms in the production of analgesia by electrical stimulation of the nucleus reticularis paragigantocellularis and nucleus raphe magnus in the rat Brain Research. ,vol. 194, pp. 525- 529 ,(1980) , 10.1016/0006-8993(80)91236-6
A. Akaike, T. Shibata, M. Satoh, H. Takagi, Analgesia induced by microinjection of morphine into, and electrical stimulation of, the nucleus reticularis paragigantocellularis of rat medulla oblongata Neuropharmacology. ,vol. 17, pp. 775- 778 ,(1978) , 10.1016/0028-3908(78)90093-X
Greg Zorman, Ian D. Hentall, John E. Adams, Howard L. Fields, Naloxone-reversible analgesia produced by microstimulation in the rat medulla Brain Research. ,vol. 219, pp. 137- 148 ,(1981) , 10.1016/0006-8993(81)90273-0
Herbert K. Proudfit, Reversible inactivation of raphe magnus neurons: effects on nociceptive threshold and morphine-induced analgesia Brain Research. ,vol. 201, pp. 459- 464 ,(1980) , 10.1016/0006-8993(80)91053-7
J.T. Cannon, G.J. Prieto, A. Lee, J.C. Liebeskind, Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat. Brain Research. ,vol. 243, pp. 315- 321 ,(1982) , 10.1016/0006-8993(82)90255-4
A. J. Castiglioi, M. C. Gallaway, J. D. Coulter, Spinal projections from the midbrain in monkey The Journal of Comparative Neurology. ,vol. 178, pp. 329- 345 ,(1978) , 10.1002/CNE.901780208
Elizabeth Taber, Alf Brodal, Fred Walberg, The raphe nuclei of the brain stem in the cat. I. Normal topography and cytoarchitecture and general discussion The Journal of Comparative Neurology. ,vol. 114, pp. 161- 187 ,(1960) , 10.1002/CNE.901140205