An analytical model for nanoparticles concentration resulting from infusion into poroelastic brain tissue.

摘要: We consider the infusion of a diluted suspension nanoparticles (NPs) into poroelastic brain tissue, in view relevant biomedical applications such as intratumoral thermotherapy. Indeed, high impact related pathologies motivates development advanced therapeutic approaches, whose design also benefits from theoretical models. This study provides an analytical expression for time-dependent NPs concentration during which accounts particle binding onto cells (by recalling results colloid filtration theory). Our model is computationally inexpensive and, compared to fully numerical permits explicitly elucidate role involved physical aspects (tissue poroelasticity, parameters, physico-chemical properties, NP-tissue interactions underlying binding). present illustrative based on parameters taken literature, by considering clinically ranges parameters. Moreover, we thoroughly assess working assumptions besides discussing its limitations. While not laying any claims generality, our can be used support more ambitious towards preliminary novel therapies tissue.