Rhodium-catalyzed [2 + 2 + 2] cycloaddition of alkenyl isocyanates and alkynes.
作者： Robert T. Yu , Tomislav Rovis
DOI: 10.1021/JA057803C
关键词:
摘要: A rhodium(I)-catalyzed [2 + 2 2] cycloaddition between alkenyl isocyanates and alkynes has been developed. Heating a mixture of an isocyanate symmetrical internal alkyne in the presence [Rh(ethylene)2Cl]2/P(4-OMe-C6H4)3 toluene delivers substituted indolizinones quinolizinones. Depending on substrates, rare fragmentation unit can be involved within process to furnish vinylogous amide embedded indolizinone.
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