Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines

摘要: Abstract New fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5- a ][1,3,5]triazin-5-amines were designed as potential anticancer agents and practical method for their preparation was developed. The reaction of benzhydrazide with cyanoguanidine followed by intramolecular cyclocondensation resulted in the formation triazolylguanidine, which upon condensation trichloroacetonitrile afforded key intermediate – 2-phenyl-7-trichloromethyl-1,2,4-triazolo[1,5- ][1,3,5]triazin-5-amine. In mild conditions, this underwent nucleophilic displacement trichloromethyl group series benzylamines providing target compounds. Antiproliferative activity prepared compounds against lung breast cancer cells explored. Together effect, some demonstrated anti-angiogenic properties.