MR fingerprinting for rapid quantification of myocardial T1, T2, and proton spin density

摘要: Purpose To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1, T2, and M0 in myocardium. Methods An electrocardiograph-triggered MRF method is introduced mapping myocardial during single breath-hold as short four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery T2 preparation dephasing times. A dictionary possible signal evolutions simulated each scan that incorporates the subject's unique variations heart rate. Aspects design were explored simulations, accuracy precision cardiac assessed phantom study. In vivo imaging was performed at 3 Tesla 11 volunteers to generate native parametric maps. Results T1 measurements from proposed correlated well with standard spin echo study (R2 > 0.99). Bland-Altman analysis revealed good agreement T1 between MOLLI (bias 1 ms, 95% limits −72 72 ms) T2-prepared balanced steady-state free precession (bias, −2.6 ms; agreement, −8.5 3.3 ms). Conclusion MRF can provide quantitative slice maps within breath-hold. Magn Reson Med 77:1446–1458, 2017. © 2016 International Society Magnetic Resonance Medicine