Quantitative contrast-enhanced MR imaging of the optic nerve

摘要: During the acute stages of optic neuritis damage to blood-optic nerve barrier can be detected using i.v. paramagnetic contrast-enhanced MR imaging. Quantification enhancement pattern nerve, intraorbital fat and muscle was determined in 15 normal subjects 3 fat-suppression imaging methods: T1-weighted spin-echo spoiled gradient-echo sequences preceded by a fat-frequency selective pulse (FATSAT+SE FATSAT+SPGR, respectively) sequence combining CHOPPER suppression with preparation (HYBRID). Pre- postcontrast-enhanced studies were acquired for FATSAT+SE FATSAT+SPGR. There no significant either method (mean increase 0.96% 5.3%, respectively), while there 118.2% 108.2%, respectively; p < 0.005) 13% 37%, 0.05). Postcontrast nerve/muscle signal intensity ratios (mean, SD) 0.51 (0.07), 0.58 (0.05) 0.75 FATSAT+SE, FATSAT+SPGR HYBRID, respectively. These results suggest practical methodology range values increases tissue that used as objective measures natural history treatment trials.