Sexual dimorphism in extent of axonal sprouting in rat hippocampus.

摘要: Sympathetic axons, normally innervating the extracerebral vasculature, sprout into denervated regions of hippocampal formation after lesions medial septal nucleus or fimbria in adult female rats. Similar males also elicit sympathetic ingrowth; however, number anomalous axons is greatly reduced and their distribution altered. In do not send out collaterals within stratum oriens region CA3 molecular layer deep hilar area dentata, as they females. Lesions juveniles both sexes result more vigorous sprouting than counterparts. young are distributed extensively dentate layer; females merely same adults. This sexually dimorphic response to central nervous system damage suggests either that affected by hormonal environment mature this brain region, like hypothalamus, may express permanent morphological physiological differences a exposure sex steroids during development.