Glucose tolerance is negatively associated with circulating progenitor cell levels

摘要: Circulating progenitor cells participate in cardiovascular homeostasis. Depletion of the pool endothelial (EPCs) is associated with increased risk. Furthermore, EPCs are reduced presence classical risk factors for atherosclerotic disease, including diabetes mellitus. This study was designed to evaluate cell levels volunteers different degrees glucose tolerance. Cardiovascular parameters and circulating CD34+ kinase insert domain receptor (KDR)+ were determined 219 middle-aged individuals no pre-diagnosed alterations carbohydrate metabolism. Glucose tolerance by fasting 2 h post-challenge levels, IFG IGT considered as pre-diabetic states. CD34+KDR+ significantly who found have mellitus, negatively correlated both whole population. While only cells, but not individuals, an independent determinant cells. healthy individuals. progenitors increasing post-meal may be one cause high incidence damage pre-diabetes.