Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival.

摘要: Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve coexpression by for pool common targeting miRNAs. Individual biological investigations implied ceRNA interaction performs crucial oncogenic/tumor suppressive functions glioblastoma multiforme (GBM). Yet, systematic analysis has not been conducted to explore functional landscape and prognostic significance interaction. Incorporating knowledge that is highly condition-specific modulated expressional abundance miRNAs, we devised inference differential correlation identify miRNA-modulated pairs. Analyzing sample-paired miRNA gene expression profiles GBM, our data showed this alternative layer essential global information flow. Functional annotation revealed its involvement activated processes brain, such as synaptic transmission, well critical tumor-associated functions. Notably, survival suggested strength ceRNA-ceRNA interactions, rather than individual ceRNAs, among three immune response (CCL22, IL2RB, IRF4) predictive patient survival. The value was validated independent cohorts. This work addresses lack comprehensive exploration into relevance GBM. proposed efficient reliable method GBM-related prognosis. highlighted roles provide basis further clinical investigations.