Assessing random error in the international normalized ratio.

摘要: Changes in the international normalized ratio (INR) following warfarin administration may be explained not only by attendant anticoagulant effect but also, part, random errors normally associated with laboratory assays. Thus, a patient's true INR will differ from reported value some error related to variability prothrombin time (PT) assay. By employing statistical technique known as delta method, expected an for particular institution can estimated taking product of sensitivity index (ISI) and coefficient variation (CV) PT