Insulin Secretion in Metabolically Obese, but Normal Weight, and in Metabolically Healthy but Obese Individuals

作者: Elena Succurro , Maria A Marini , Simona Frontoni , Marta L Hribal , Francesco Andreozzi

DOI: 10.1038/OBY.2008.308

关键词:

摘要: Metabolically obese but normal-weight (MONW) individuals present metabolic disturbances typical of individuals. Additionally, metabolically healthy (MHO) have been identified who are relatively insulin sensitive and a favorable cardiovascular risk profile. We compared secretion patterns MONW MHO with those two age-matched groups comprising nonobese or insulin-resistant subjects, respectively. To this end, 110 subjects 87 were stratified into quartile based on their insulin-stimulated glucose disposal (M(FFM)). Insulin was estimated by acute response (AIR) during an intravenous glucose-tolerance test (IVGTT), the disposition index calculated as AIR x M(FFM). found that, defined, M(FFM) lower in MONW, exhibited higher triglycerides, free-fatty acid (FFA), 2-h postchallenge levels to normal group. than MONW. Disposition did not differ between obese. waist circumference, blood pressure (BP), FFA, levels, high-density lipoprotein (HDL) cholesterol MHO, former In conclusion, showed decreased compensatory Because these also worse profile, findings may account for increased type 2 diabetes.

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