Effects of captopril, telmisartan and bardoxolone methyl (CDDO‐Me) in ischemia‐reperfusion‐induced acute kidney injury in rats: an experimental comparative study

摘要: Renal ischemia-reperfusion (IR) injury is one of the most common causes acute kidney injury. This study investigated effects captopril (CAP), telmisartan (TEL) and bardoxolone methyl (BM) in animals with renal IR Adult male Wistar-Albino rats were divided into six groups: control, vehicle, IR, CAP, TEL BM. Before was induced, drugs administered by oral gavage. After a 60-min ischemia 120-min reperfusion period, bilateral nephrectomies performed. Serum urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL) levels, tissue total oxidant status (TOS), antioxidant (TAS), thiol (TT), asymmetric dimethylarginine (ADMA) superoxide dismutase (SOD) activity glutathione peroxidase (GSH-Px) measured. Tissue mRNA expression levels peroxisome proliferator-activated receptor-ɣ (PPAR-ɣ), nuclear factor erythroid 2-related 2 (Nrf2) kappa-light-chain-enhancer activated B cells (NF-κB) analyzed. In addition, tissues evaluated histopathologically immunohistochemically. All tested reduced damage, apoptosis, NGAL, TOS, nitric oxide (NO) ADMA NF-κB, inducible synthase (iNOS) endothelin-1 (ET-1) expressions (P < 0.001). increased SOD activity, GSH-Px TAS TT endothelial (eNOS) expression, dimethylaminohydrolases (DDAHs) Nrf2 PPAR-ɣ 0.001, P 0.003). These results suggest that BM pretreatment could reduce via anti-inflammatory, anti-apoptotic effects.