Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics.
作者： Shengzhe Zhao , Xujiang Yu , Yuna Qian , Wei Chen , Jianliang Shen
DOI: 10.7150/THNO.42564
关键词:
摘要: Multifunctional magnetic nanoparticles and derivative nanocomposites have aroused great concern for multimode imaging cancer synergistic therapies in recent years. Among the rest, functional iron oxide (Fe3O4 NPs) shown potential as an advanced platform because of their inherent resonance (MRI), biocatalytic activity (nanozyme), hyperthermia treatment (MHT), photo-responsive therapy drug delivery chemotherapy gene therapy. Magnetic Fe3O4 NPs can be synthesized through several methods easily surface modified with biocompatible materials or active targeting moieties. The MRI capacity could appropriately modulated to induce response between T 1 2 modes by controlling size distribution NPs. Besides, small-size are also desired due enhanced permeation retention (EPR) effect, thus therapeutic efficiency NP-based platforms further improved. Here, we firstly retrospect typical synthesis modification Then, latest biomedical application including responsive MRI, multimodal imaging, nanozyme, MHT, delivery, mechanism corresponding treatments cooperation therapeutics multifunctional explained. Finally, outline a brief discussion perspective on possibility clinical translations these nanomaterials. This review would provide comprehensive reference readers understand diagnosis treatment.
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