Antipsychotic drugs and dopamine-stimulated adenylate cyclase prepared from corpus striatum of rat brain.

摘要: Abstract Antipsychotic drugs and their clinically impotent congeners were examined as inhibitors of dopamine-sensitive adenylate cyclase (EC 4.6.1.1) in cell-free membrane preparations the caudate-putamen rat brain. Of 12 neuroleptic with reported antipsychotic efficacy, all inhibit stimulation by 40 μM dopamine at micromolar concentrations. Among 14 other structurally related that are not effective agents, almost ineffective while two moderate cyclase.