In vivo degradation of a poly(propylene fumarate)/β‐tricalcium phosphate injectable composite scaffold
作者： Susan J. Peter , Seth T. Miller , Guoming Zhu , Alan W. Yasko , Antonios G. Mikos
DOI: 10.1002/(SICI)1097-4636(199807)41:1<1::AID-JBM1>3.0.CO;2-N
关键词:
摘要: This study was designed to investigate the in vivo biodegration and biocompatibility of a poly(propylene fumarate) (PPF)-based orthopedic biomaterial. The effects varying PPF N-vinyl pyrrolidinone ratio β-tricalcium phosphate content were studied. composite mechanical properties local tissue interactions analyzed over 12 weeks. An initial increase both compressive modulus strength seen for formulations that incorporated phosphate. samples incorporating higher reached maximal 7.7 MPa 191.4 at 3 lower gained maximum 7.5 initially 134.0 1 week. At 6 weeks, all crumbled upon removal not mechanically tested. Samples did incorporate very weak insufficient bone replacement 4-day time point beyond. Tissue resulted mild inflammatory response points mature fibrous encapsulation by © 1998 John Wiley & Sons, Inc. J. Biomed Mater Res, 41, 1–7, 1998.
sci-hub.se 参考文章(9)
W Petty, S Spanier, J J Shuster, C Silverthorne, The influence of skeletal implants on incidence of infection. Experiments in a canine model. Journal of Bone and Joint Surgery, American Volume. ,vol. 67, pp. 1236- 1244 ,(1985) , 10.2106/00004623-198567080-00015
W Petty, S Spanier, J J Shuster, Prevention of infection after total joint replacement. Experiments with a canine model. Journal of Bone and Joint Surgery, American Volume. ,vol. 70, pp. 536- 539 ,(1988) , 10.2106/00004623-198870040-00009
Michael J. Yaszemski, Richard G. Payne, Wilson C. Hayes, Robert S. Langer, Thomas B. Aufdemorte, Antonios G. Mikos, The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold. Tissue Engineering. ,vol. 1, pp. 41- 52 ,(1995) , 10.1089/TEN.1995.1.41
J. DENNIS BOBYN, ERROL S. MORTIMER, ANDREW H. GLASSMAN, CHARLES A. ENGH, JOSEPH E. MILLER, C. EMERSON BROOKS, Producing and avoiding stress shielding. Laboratory and clinical observations of noncemented total hip arthroplasty Clinical Orthopaedics and Related Research. ,vol. 274, pp. 79- 96 ,(1992) , 10.1097/00003086-199201000-00010
Steven A. Goldstein, Douglas L. Wilson, David A. Sonstegard, Larry S. Matthews, The mechanical properties of human tibial trabecular bone as a function of metaphyseal location. Journal of Biomechanics. ,vol. 16, pp. 965- 969 ,(1983) , 10.1016/0021-9290(83)90097-0
Susan J. Peter, Michael J. Yaszemski, Laura J. Suggs, Richard G. Payne, Robert Langer, Wilson C. Hayes, Marilyn R. Unroe, Lawrence B. Alemany, Paul S. Engel, Antonios G. Mikos, CHARACTERIZATION OF PARTIALLY SATURATED POLY(PROPYLENE FUMARATE) FOR ORTHOPAEDIC APPLICATION Journal of Biomaterials Science-polymer Edition. ,vol. 8, pp. 893- 904 ,(1997) , 10.1163/156856297X00074
Susan J. Peter, Jessica A. Nolley, Markus S. Widmer, John E. Merwin, Michael J. Yaszemski, Alan W. Yasko, Paul S. Engel, Antonios G. Mikos, In vitro degradation of a poly(propylene fumarate)/β-tricalcium phosphate composite orthopaedic scaffold Tissue Engineering. ,vol. 3, pp. 207- 215 ,(1997) , 10.1089/TEN.1997.3.207
Michael J. Yaszemski, Richard G. Payne, Wilson C. Hayes, Robert Langer, Antonios G. Mikos, In vitro degradation of a poly(propylene fumarate)-based composite material Biomaterials. ,vol. 17, pp. 2127- 2130 ,(1996) , 10.1016/0142-9612(96)00008-7
JAMES M. ANDERSON, ANTHONY G. GRISTINA, STEPHEN R. HANSON, LAURENCE A. HARKER, RICHARD J. JOHNSON, KATHARINE MERRITT, PAUL T. NAYLOR, FREDERICK J. SCHOEN, Host Reactions to Biomaterials and Their Evaluation Biomaterials Science#R##N#An Introduction to Materials in Medicine. pp. 165- 214 ,(1996) , 10.1016/B978-0-08-050014-0.50009-2